ODCs

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4 OMIM references -
1 associated gene
2 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

2 OMIM references -
2 associated genes
7 signs/symptoms

Hereditary gingival fibromatosis

Isolated trigonocephaly

SOS1	(UniProt - OMIM)		FGFR1	(UniProt - OMIM)
			FREM1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	SOS1	(0.52)	FGFR1

Citations in the biomedical literature:

Hereditary gingival fibromatosis		Isolated trigonocephaly
	Synonym(s): - Autosomal dominant gingival fibromatosis - Autosomal dominant gingival hyperplasia - Hereditary gingival hyperplasia		Synonym(s): - Non-syndromic metopic craniosynostosis

	Classification (Orphanet): - Rare genetic disease - Rare odontologic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease

	Classification (ICD10): - Diseases of the digestive system -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant

	External references: 4 OMIM references - No MeSH references		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Hereditary gingival fibromatosis		Isolated trigonocephaly
	Very frequent - Thickened / hypertrophic / fibromatous gingivae		Very frequent - Trigonocephaly Frequent - Broad nasal root - Hypotelorism - Prominent supraorbital ridge - Synophris / synophrys Occasional - Omphalocele / exomphalos